Positive and Negative Regulatory Roles of C-Terminal Src Kinase (CSK) in FcεRI-Mediated Mast Cell Activation, Independent of the Transmembrane Adaptor PAG/CSK-Binding Protein

C-terminal Src kinase (CSK) is a major negative regulator of Src family tyrosine kinases (SFKs) that play critical roles in immunoreceptor signaling. CSK is brought in contiguity to the plasma membrane-bound SFKs via binding to transmembrane adaptor PAG, also known as CSK-binding protein. The recent...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Potuckova, Lucie, Draberova, Lubica, Halova, Ivana, Paulenda, Tomas, Draber, Petr
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6082945/
https://ncbi.nlm.nih.gov/pubmed/30116247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01771
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