Binding of WIP to Actin Is Essential for T Cell Actin Cytoskeleton Integrity and Tissue Homing

The Wiskott-Aldrich syndrome protein (WASp) is important for actin polymerization in T cells and for their migration. WASp-interacting protein (WIP) binds to and stabilizes WASp and also interacts with actin. Cytoskeletal and functional defects are more severe in WIP(−/−) T cells, which lack WASp, t...

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Udgivet i:Mol Cell Biol
Main Authors: Massaad, Michel J., Oyoshi, Michiko K., Kane, Jennifer, Koduru, Suresh, Alcaide, Pilar, Nakamura, Fumihiko, Ramesh, Narayanaswamy, Luscinskas, Francis W., Hartwig, John, Geha, Raif S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248745/
https://ncbi.nlm.nih.gov/pubmed/25246631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00533-14
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