An Endoplasmic Reticulum Stress-Initiated Sphingolipid Metabolite, Ceramide-1-Phosphate, Regulates Epithelial Innate Immunity by Stimulating β-Defensin Production

Antimicrobial peptides (AMP) are ubiquitous innate immune elements in epithelial tissues. We recently discovered that a signaling lipid, the ceramide metabolite sphingosine-1-phosphate (S1P), regulates production of a major AMP, cathelicidin antimicrobial peptide (CAMP), in response to a subtoxic le...

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Bibliografiska uppgifter
I publikationen:Mol Cell Biol
Huvudupphovsmän: Kim, Young-Il, Park, Kyungho, Kim, Jong Youl, Seo, Ho Seong, Shin, Kyong-Oh, Lee, Yong-Moon, Holleran, Walter M., Elias, Peter M., Uchida, Yoshikazu
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2014
Ämnen:
Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248733/
https://ncbi.nlm.nih.gov/pubmed/25312644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00599-14
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