Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α

Increased PI 3-kinase (PI3K) signaling in pancreatic ductal adenocarcinoma (PDAC) correlates with poor prognosis, but the role of class I PI3K isoforms during its induction remains unclear. Using genetically engineered mice and pharmacological isoform-selective inhibitors, we found that the p110α PI...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Genes Dev
Prif Awduron: Baer, Romain, Cintas, Célia, Dufresne, Marlène, Cassant-Sourdy, Stéphanie, Schönhuber, Nina, Planque, Laetitia, Lulka, Hubert, Couderc, Bettina, Bousquet, Corinne, Garmy-Susini, Barbara, Vanhaesebroeck, Bart, Pyronnet, Stéphane, Saur, Dieter, Guillermet-Guibert, Julie
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2014
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248293/
https://ncbi.nlm.nih.gov/pubmed/25452273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.249409.114
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg