Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α

Increased PI 3-kinase (PI3K) signaling in pancreatic ductal adenocarcinoma (PDAC) correlates with poor prognosis, but the role of class I PI3K isoforms during its induction remains unclear. Using genetically engineered mice and pharmacological isoform-selective inhibitors, we found that the p110α PI...

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Veröffentlicht in:Genes Dev
Hauptverfasser: Baer, Romain, Cintas, Célia, Dufresne, Marlène, Cassant-Sourdy, Stéphanie, Schönhuber, Nina, Planque, Laetitia, Lulka, Hubert, Couderc, Bettina, Bousquet, Corinne, Garmy-Susini, Barbara, Vanhaesebroeck, Bart, Pyronnet, Stéphane, Saur, Dieter, Guillermet-Guibert, Julie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2014
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248293/
https://ncbi.nlm.nih.gov/pubmed/25452273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.249409.114
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