Impact of G-quadruplex structures and intronic polymorphisms rs17878362 and rs1642785 on basal and ionizing radiation-induced expression of alternative p53 transcripts

G-quadruplex (G4) structures in intron 3 of the p53 pre-mRNA modulate intron 2 splicing, altering the balance between the fully spliced p53 transcript (FSp53, encoding full-length p53) and an incompletely spliced transcript retaining intron 2 (p53I2 encoding the N-terminally truncated Δ40p53 isoform...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Carcinogenesis
Hoofdauteurs: Perriaud, Laury, Marcel, Virginie, Sagne, Charlotte, Favaudon, Vincent, Guédin, Aurore, De Rache, Aurore, Guetta, Corinne, Hamon, Florian, Teulade-Fichou, Marie-Paule, Hainaut, Pierre, Mergny, Jean-Louis, Hall, Janet
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2014
Onderwerpen:
Original Manuscript
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4247521/
https://ncbi.nlm.nih.gov/pubmed/25269805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgu206
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items