Impact of G-quadruplex structures and intronic polymorphisms rs17878362 and rs1642785 on basal and ionizing radiation-induced expression of alternative p53 transcripts

G-quadruplex (G4) structures in intron 3 of the p53 pre-mRNA modulate intron 2 splicing, altering the balance between the fully spliced p53 transcript (FSp53, encoding full-length p53) and an incompletely spliced transcript retaining intron 2 (p53I2 encoding the N-terminally truncated Δ40p53 isoform...

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Dettagli Bibliografici
Pubblicato in:Carcinogenesis
Autori principali: Perriaud, Laury, Marcel, Virginie, Sagne, Charlotte, Favaudon, Vincent, Guédin, Aurore, De Rache, Aurore, Guetta, Corinne, Hamon, Florian, Teulade-Fichou, Marie-Paule, Hainaut, Pierre, Mergny, Jean-Louis, Hall, Janet
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
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Original Manuscript
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4247521/
https://ncbi.nlm.nih.gov/pubmed/25269805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgu206
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