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Anticancer drug mithramycin interacts with core histones: An additional mode of action of the DNA groove binder
Mithramycin (MTR) is a clinically approved DNA-binding antitumor antibiotic currently in Phase 2 clinical trials at National Institutes of Health for treatment of osteosarcoma. In view of the resurgence in the studies of this generic antibiotic as a human medicine, we have examined the binding prope...
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| Publicado no: | FEBS Open Bio |
|---|---|
| Principais autores: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4247356/ https://ncbi.nlm.nih.gov/pubmed/25473595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2014.10.007 |
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