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A Genetic Variant of p53 Restricts the Mucus Secretory Phenotype by Regulating SPDEF and Bcl-2 Expression
Despite implications for carcinogenesis and other chronic diseases, basic mechanisms of p53 and its variants in suppressing Bcl-2 levels, are poorly understood. Bcl-2 sustains mucous cell metaplasia, whereas p53(−/−) mice display chronically increased mucous cells. Here we show that p53 decreases bc...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4247165/ https://ncbi.nlm.nih.gov/pubmed/25429397 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6567 |
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