FOLFIRI and regorafenib combination therapy with dose escalation of irinotecan as fourth-line treatment for patients with metastatic colon cancer according to UGT1A1 genotyping

Here we report a case of metastatic colon cancer treated with 5-fluorouracil, leucovorin, and escalated doses of irinotecan (FOLFIRI) combined with regorafenib in the fourth-line setting after uridine diphosphate glucuronosyltransferase (UGT)1A1 genotyping analysis. A 66-year-old male was initially...

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Bibliographische Detailangaben
Veröffentlicht in:Onco Targets Ther
Hauptverfasser: Lu, Chien-Yu, Yeh, Yung-Sung, Huang, Ching-Wen, Ma, Cheng-Jen, Yu, Fang-Jung, Wang, Jaw-Yuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2014
Schlagworte:
Case Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246994/
https://ncbi.nlm.nih.gov/pubmed/25473295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S69774
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