Staphylococcus aureus secretes a unique class of neutrophil serine protease inhibitors

Neutrophils are indispensable for clearing infections with the prominent human pathogen Staphylococcus aureus. Here, we report that S. aureus secretes a family of proteins that potently inhibits the activity of neutrophil serine proteases (NSPs): neutrophil elastase (NE), proteinase 3, and cathepsin...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Stapels, Daphne A. C., Ramyar, Kasra X., Bischoff, Markus, von Köckritz-Blickwede, Maren, Milder, Fin J., Ruyken, Maartje, Eisenbeis, Janina, McWhorter, William J., Herrmann, Mathias, van Kessel, Kok P. M., Geisbrecht, Brian V., Rooijakkers, Suzan H. M.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2014
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246989/
https://ncbi.nlm.nih.gov/pubmed/25161283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1407616111
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