Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes

Peroxisome proliferator-activated receptor gamma (PPARG) is a master transcriptional regulator of adipocyte differentiation and a canonical target of antidiabetic thiazolidinedione medications. In rare families, loss-of-function (LOF) mutations in PPARG are known to cosegregate with lipodystrophy an...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Majithia, Amit R., Flannick, Jason, Shahinian, Peter, Guo, Michael, Bray, Mark-Anthony, Fontanillas, Pierre, Gabriel, Stacey B., Rosen, Evan D., Altshuler, David
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246964/
https://ncbi.nlm.nih.gov/pubmed/25157153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410428111
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