Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes

Peroxisome proliferator-activated receptor gamma (PPARG) is a master transcriptional regulator of adipocyte differentiation and a canonical target of antidiabetic thiazolidinedione medications. In rare families, loss-of-function (LOF) mutations in PPARG are known to cosegregate with lipodystrophy an...

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書目詳細資料
發表在:Proc Natl Acad Sci U S A
Main Authors: Majithia, Amit R., Flannick, Jason, Shahinian, Peter, Guo, Michael, Bray, Mark-Anthony, Fontanillas, Pierre, Gabriel, Stacey B., Rosen, Evan D., Altshuler, David
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2014
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246964/
https://ncbi.nlm.nih.gov/pubmed/25157153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410428111
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