Overactivation of corticotropin-releasing factor receptor type 1 and aquaporin-4 by hypoxia induces cerebral edema

Cerebral edema is a potentially life-threatening illness, but knowledge of its underlying mechanisms is limited. Here we report that hypobaric hypoxia induces rat cerebral edema and neuronal apoptosis and increases the expression of corticotrophin releasing factor (CRF), CRF receptor type 1 (CRFR1),...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Chen, Shao-Jun, Yang, Jia-Fang, Kong, Fan-Ping, Ren, Ji-Long, Hao, Ke, Li, Min, Yuan, Yuan, Chen, Xin-Can, Yu, Ri-Sheng, Li, Jun-Fa, Leng, Gareth, Chen, Xue-Qun, Du, Ji-Zeng
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246936/
https://ncbi.nlm.nih.gov/pubmed/25146699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1404493111
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