Overactivation of corticotropin-releasing factor receptor type 1 and aquaporin-4 by hypoxia induces cerebral edema

Cerebral edema is a potentially life-threatening illness, but knowledge of its underlying mechanisms is limited. Here we report that hypobaric hypoxia induces rat cerebral edema and neuronal apoptosis and increases the expression of corticotrophin releasing factor (CRF), CRF receptor type 1 (CRFR1),...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Chen, Shao-Jun, Yang, Jia-Fang, Kong, Fan-Ping, Ren, Ji-Long, Hao, Ke, Li, Min, Yuan, Yuan, Chen, Xin-Can, Yu, Ri-Sheng, Li, Jun-Fa, Leng, Gareth, Chen, Xue-Qun, Du, Ji-Zeng
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246936/
https://ncbi.nlm.nih.gov/pubmed/25146699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1404493111
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