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Discovery of GPCR ligands for probing signal transduction pathways
G protein-coupled receptors (GPCRs) are seven integral transmembrane proteins that are the primary targets of almost 30% of approved drugs and continue to represent a major focus of pharmaceutical research. All of GPCR targeted medicines were discovered by classical medicinal chemistry approaches. A...
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| Publicado en: | Front Pharmacol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Frontiers Media S.A.
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4246677/ https://ncbi.nlm.nih.gov/pubmed/25506327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2014.00255 |
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