A MOLECULAR BIOLOGY AND PHASE II TRIAL OF LAPATINIB IN CHILDREN WITH REFRACTORY CNS MALIGNANCIES: A PEDIATRIC BRAIN TUMOR CONSORTIUM STUDY

BACKGROUND: High expression of ERBB2 has been reported in medulloblastoma and ependymoma; EGFR is amplified and over-expressed in brainstem glioma suggesting these proteins as potential therapeutic targets. We conducted a molecular biology (MB) and phase II study to estimate inhibition of tumor ERBB...

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Gepubliceerd in:J Neurooncol
Hoofdauteurs: Fouladi, Maryam, Stewart, Clinton F., Blaney, Susan M., Onar-Thomas, Arzu, Schaiquevich, Paula, Packer, Roger J., Goldman, Stewart, Geyer, J. Russell, Gajjar, Amar, Kun, Larry E., Boyett, James M., Gilbertson, Richard J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246636/
https://ncbi.nlm.nih.gov/pubmed/23836190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-013-1166-7
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