Physiological levels of lipoxin A(4) inhibit ENaC and restore airway surface liquid height in cystic fibrosis bronchial epithelium

In cystic fibrosis (CF), the airway surface liquid (ASL) is depleted. We previously demonstrated that lipoxin A(4) (LXA(4)) can modulate ASL height (ASLh) through actions on Cl(−) transport. Here, we report novel effects of lipoxin on the epithelial Na(+) channel ENaC in this response. ASL dynamics...

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Detalhes bibliográficos
Publicado no:Physiol Rep
Main Authors: Al‐Alawi, Mazen, Buchanan, Paul, Verriere, Valia, Higgins, Gerard, McCabe, Olive, Costello, Richard W., McNally, Paul, Urbach, Valérie, Harvey, Brian J.
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Periodicals, Inc. 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246599/
https://ncbi.nlm.nih.gov/pubmed/25107986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12093
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