A DNA repair variant in POLQ (c.-1060A > G) is associated to hereditary breast cancer patients: a case–control study

BACKGROUND: One of the hallmarks of cancer is the occurrence of high levels of chromosomal rearrangements as a result of inaccurate repair of double-strand breaks (DSB). Germline mutations in BRCA and RAD51 genes, involved in DSB repair, are strongly associated with hereditary breast cancer. Pol θ,...

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Udgivet i:BMC Cancer
Main Authors: Brandalize, Ana Paula Carneiro, Schüler-Faccini, Lavínia, Hoffmann, Jean-Sébastien, Caleffi, Maira, Cazaux, Christophe, Ashton-Prolla, Patricia
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246548/
https://ncbi.nlm.nih.gov/pubmed/25409685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-850
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