Molecular insights into DNA interference by CRISPR-associated nuclease-helicase Cas3

Mobile genetic elements in bacteria are neutralized by a system based on clustered regularly interspaced short palindromic repeats (CRISPRs) and CRISPR-associated (Cas) proteins. Type I CRISPR-Cas systems use a “Cascade” ribonucleoprotein complex to guide RNA specifically to complementary sequence i...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Gong, Bei, Shin, Minsang, Sun, Jiali, Jung, Che-Hun, Bolt, Edward L., van der Oost, John, Kim, Jeong-Sun
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2014
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246338/
https://ncbi.nlm.nih.gov/pubmed/25368186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410806111
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