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Differential gradients of interaction affinities drive efficient targeting and recycling in the GET pathway

Efficient and accurate localization of membrane proteins requires a complex cascade of interactions between protein machineries. This requirement is exemplified in the guided entry of tail-anchored (TA) protein (GET) pathway, where the central targeting factor Get3 must sequentially interact with th...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Rome, Michael E., Chio, Un Seng, Rao, Meera, Gristick, Harry, Shan, Shu-ou
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246279/
https://ncbi.nlm.nih.gov/pubmed/25368153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1411284111
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