Simultaneous Inhibition of T Helper 2 and T Regulatory Cell Differentiation by Small Molecules Enhances Bacillus Calmette-Guerin Vaccine Efficacy against Tuberculosis

Tuberculosis affects nine million individuals and kills almost two million people every year. The only vaccine available, Bacillus Calmette-Guerin (BCG), has been used since its inception in 1921. Although BCG induces host-protective T helper 1 (Th1) cell immune responses, which play a central role...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Bhattacharya, Debapriya, Dwivedi, Ved Prakash, Kumar, Santosh, Reddy, Madhava C., Van Kaer, Luc, Moodley, Prashini, Das, Gobardhan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246096/
https://ncbi.nlm.nih.gov/pubmed/25315774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.600452
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