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Cdx1 and Cdx2 Function as Tumor Suppressors

In humans, colorectal cancer is often initiated through APC loss of function, which leads to crypt hyperplasia and polyposis driven by unrestricted canonical Wnt signaling. Such polyps typically arise in the colorectal region and are at risk of transforming to invasive adenocarcinomas. Although colo...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Hryniuk, Alexa, Grainger, Stephanie, Savory, Joanne G. A., Lohnes, David
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246091/
https://ncbi.nlm.nih.gov/pubmed/25320087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.583823
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