Deletion of Leucine Zipper Tumor Suppressor 2 (Lzts2) Increases Susceptibility to Tumor Development

Using an Lzts2 knock-out mouse model, we characterized the biological role of Lzts2 in tumorigenesis. Both heterozygous and homozygous deletion of the Lzts2-targeted allele in mice shows an increased incidence in spontaneous tumor development, although Lzts2 homozygous knock-out mice show significan...

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Main Authors: Johnson, Daniel T., Luong, Richard, Lee, Suk Hyung, Peng, Yue, Shaltouki, Atossa, Lee, Jane T., Lin, Dong, Wang, Yuzhuo, Sun, Zijie
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Molecular Bases of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567628/
https://ncbi.nlm.nih.gov/pubmed/23275340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.417568
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