Structure-based Conversion of the Coenzyme Requirement of a Short-chain Dehydrogenase/Reductase Involved in Bacterial Alginate Metabolism

The alginate-assimilating bacterium, Sphingomonas sp. strain A1, degrades the polysaccharides to monosaccharides through four alginate lyase reactions. The resultant monosaccharide, which is nonenzymatically converted to 4-deoxy-l-erythro-5-hexoseulose uronate (DEH), is further metabolized to 2-keto...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Takase, Ryuichi, Mikami, Bunzo, Kawai, Shigeyuki, Murata, Kousaku, Hashimoto, Wataru
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246080/
https://ncbi.nlm.nih.gov/pubmed/25288804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.585661
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