Crucial role of 4-deoxy-L-erythro-5-hexoseulose uronate reductase for alginate utilization revealed by adaptive evolution in engineered Saccharomyces cerevisiae

In brown macroalgae, alginate and D-mannitol are promising carbohydrates for biorefinery. Saccharomyces cerevisiae is widely used as a microbial cell factory, but this budding yeast is unable to utilize either alginate or D-mannitol. Alginate can be depolymerized by both endo-type and exo-type algin...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Matsuoka, Fumiya, Hirayama, Makoto, Kashihara, Takayuki, Tanaka, Hideki, Hashimoto, Wataru, Murata, Kousaku, Kawai, Shigeyuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482797/
https://ncbi.nlm.nih.gov/pubmed/28646149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04481-3
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