Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition

For most children who relapse with acute lymphoblastic leukemia (ALL), the prognosis is poor, and there is a need for novel therapies to improve outcome. We screened samples from children with B-lineage ALL entered into the ALL-REZ BFM 2002 clinical trial (www.clinicaltrials.gov, #NCT00114348) for s...

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Vydáno v:Blood
Hlavní autoři: Irving, Julie, Matheson, Elizabeth, Minto, Lynne, Blair, Helen, Case, Marian, Halsey, Christina, Swidenbank, Isabella, Ponthan, Frida, Kirschner-Schwabe, Renate, Groeneveld-Krentz, Stefanie, Hof, Jana, Allan, James, Harrison, Christine, Vormoor, Josef, von Stackelberg, Arend, Eckert, Cornelia
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2014
Témata:
Lymphoid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246039/
https://ncbi.nlm.nih.gov/pubmed/25253770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-531871
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