A Relationship between the Transient Structure in the Monomeric State and the Aggregation Propensities of α-Synuclein and β-Synuclein

[Image: see text] α-Synuclein is an intrinsically disordered protein whose aggregation is implicated in Parkinson’s disease. A second member of the synuclein family, β-synuclein, shares significant sequence similarity with α-synuclein but is much more resistant to aggregation. β-Synuclein is missing...

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Argitaratua izan da:Biochemistry
Egile Nagusiak: Allison, Jane R., Rivers, Robert C., Christodoulou, John C., Vendruscolo, Michele, Dobson, Christopher M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2014
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4245978/
https://ncbi.nlm.nih.gov/pubmed/25389903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi5009326
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