Chk2 and REGγ-dependent DBC1 regulation in DNA damage induced apoptosis

Human DBC1 (Deleted in Breast Cancer 1; KIAA1967; CCAR2) is a protein implicated in the regulation of apoptosis, transcription and histone modifications. Upon DNA damage, DBC1 is phosphorylated by ATM/ATR on Thr454 and this modification increases its inhibitory interaction with SIRT1, leading to p53...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Magni, Martina, Ruscica, Vincenzo, Buscemi, Giacomo, Kim, Ja-Eun, Nachimuthu, Benjamin Tamilselvan, Fontanella, Enrico, Delia, Domenico, Zannini, Laura
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4245943/
https://ncbi.nlm.nih.gov/pubmed/25361978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1065
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