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Synergistic modulation of cyclobutane pyrimidine dimer photoproduct formation and deamination at a T(m)CG site over a full helical DNA turn in a nucleosome core particle
Sunlight-induced C to T mutation hotspots in skin cancers occur primarily at methylated CpG sites that coincide with sites of UV-induced cyclobutane pyrimidine dimer (CPD) formation. The C or 5-methyl-C in CPDs are not stable and deaminate to U and T, respectively, which leads to the insertion of A...
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| Published in: | Nucleic Acids Res |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4245940/ https://ncbi.nlm.nih.gov/pubmed/25389265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1049 |
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