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Purifying Selection on Splice-Related Motifs, Not Expression Level nor RNA Folding, Explains Nearly All Constraint on Human lincRNAs

There are two strong and equally important predictors of rates of human protein evolution: The amount the gene is expressed and the proportion of exonic sequence devoted to control splicing, mediated largely by selection on exonic splice enhancer (ESE) motifs. Is the same true for noncoding RNAs, kn...

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Pubblicato in:Mol Biol Evol
Autori principali: Schüler, Andreas, Ghanbarian, Avazeh T., Hurst, Laurence D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4245815/
https://ncbi.nlm.nih.gov/pubmed/25158797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msu249
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