ADAR1 enhances HTLV-1 and HTLV-2 replication through inhibition of PKR activity

BACKGROUND: The role of innate immunity in general and of type I interferon (IFN-I) in particular in HTLV-1 pathogenesis is still a matter of debate. ADAR1-p150 is an Interferon Stimulated Gene (ISG) induced by IFN-I that can edit viral RNAs. We therefore investigated whether it could play the role...

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Detalhes bibliográficos
Publicado no:Retrovirology
Main Authors: Cachat, Anne, Alais, Sandrine, Chevalier, Sébastien Alain, Journo, Chloé, Fusil, Floriane, Dutartre, Hélène, Boniface, Adrien, Ko, Nga Ling, Gessain, Antoine, Cosset, François-Loïc, Suspène, Rodolphe, Vartanian, Jean-Pierre, Mahieux, Renaud
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4245799/
https://ncbi.nlm.nih.gov/pubmed/25389016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-014-0093-9
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