Distinct Conformational Behaviors of Four Mammalian Dual-Flavin Reductases (Cytochrome P450 Reductase, Methionine Synthase Reductase, Neuronal Nitric Oxide Synthase, Endothelial Nitric Oxide Synthase) Determine their Unique Catalytic Profiles

Multi-domain enzymes often rely on large conformational motions to function. However, the conformational setpoints, rates of domain motions, and relationships between these parameters and catalytic activity is not well understood. To address this, we determined and compared the conformational setpoi...

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Veröffentlicht in:FEBS J
Hauptverfasser: Haque, Mohammad Mahfuzul, Bayachou, Mekki, Tejero, Jesus, Kenney, Claire, Pearl, Naw May, Im, Sang-Choul, Waskell, Lucy, Stuehr, Dennis J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4245374/
https://ncbi.nlm.nih.gov/pubmed/25265015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.13073
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