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Advancements in the Development of HIF-1α-Activated Protein Switches for Use in Enzyme Prodrug Therapy

While gene-directed enzyme prodrug therapy has shown potential as a cancer therapeutic in animal and clinical trials, concerns over the efficacy, selectivity, and safety of gene delivery vehicles have restricted its advance. In an attempt to relieve some of the demands on targeted gene delivery vehi...

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Publicado en:PLoS One
Main Authors: Wright, R. Clay, Khakhar, Arjun, Eshleman, James R., Ostermeier, Marc
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4245239/
https://ncbi.nlm.nih.gov/pubmed/25426963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114032
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