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Specificity and Autoregulation of Notch Binding by Tandem WW Domains in Suppressor of Deltex

WW domains target proline-tyrosine (PY) motifs and frequently function as tandem pairs. When studied in isolation, single WW domains are notably promiscuous and regulatory mechanisms are undoubtedly required to ensure selective interactions. Here, we show that the fourth WW domain (WW4) of Suppresso...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Jennings, Martin D., Blankley, Richard T., Baron, Martin, Golovanov, Alexander P., Avis, Johanna M.
Format: Artigo
Language:Inglês
Published: 2007
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4244684/
https://ncbi.nlm.nih.gov/pubmed/17656366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M703453200
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