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Specificity and Autoregulation of Notch Binding by Tandem WW Domains in Suppressor of Deltex

WW domains target proline-tyrosine (PY) motifs and frequently function as tandem pairs. When studied in isolation, single WW domains are notably promiscuous and regulatory mechanisms are undoubtedly required to ensure selective interactions. Here, we show that the fourth WW domain (WW4) of Suppresso...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Jennings, Martin D., Blankley, Richard T., Baron, Martin, Golovanov, Alexander P., Avis, Johanna M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4244684/
https://ncbi.nlm.nih.gov/pubmed/17656366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M703453200
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