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In Silico Screening for Inhibitors of P-Glycoprotein That Target the Nucleotide Binding Domains

Multidrug resistances and the failure of chemotherapies are often caused by the expression or overexpression of ATP-binding cassette transporter proteins such as the multidrug resistance protein, P-glycoprotein (P-gp). P-gp is expressed in the plasma membrane of many cell types and protects cells fr...

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Библиографические подробности
Опубликовано в: :Mol Pharmacol
Главные авторы: Brewer, Frances K., Follit, Courtney A., Vogel, Pia D., Wise, John G.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2014
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4244591/
https://ncbi.nlm.nih.gov/pubmed/25270578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.095414
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