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Partial Loss of Presenilin Impairs Age-Dependent Neuronal Survival in the Cerebral Cortex
Mutations in the presenilin (PSEN1 and PSEN2) genes are linked to familial Alzheimer's disease (AD) and cause loss of its essential function. Complete inactivation of presenilins in excitatory neurons of the adult mouse cerebral cortex results in progressive memory impairment and age-dependent...
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| Publicat a: | J Neurosci |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Society for Neuroscience
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4244465/ https://ncbi.nlm.nih.gov/pubmed/25429133 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3261-14.2014 |
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