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Presenilins are Essential for Regulating Neurotransmitter Release
Mutations in the presenilin genes are the major cause of familial Alzheimer's disease (AD). Loss of presenilin activity and/or accumulation of amyloid-β peptides have been proposed to mediate the pathogenesis of AD by impairing synaptic function1-5. However, the precise site and nature of the s...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2744588/ https://ncbi.nlm.nih.gov/pubmed/19641596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08177 |
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