Dietary restriction involves NAD(+)-dependent mechanisms and a shift toward oxidative metabolism

Interventions that slow aging and prevent chronic disease may come from an understanding of how dietary restriction (DR) increases lifespan. Mechanisms proposed to mediate DR longevity include reduced mTOR signaling, activation of the NAD(+)-dependent deacylases known as sirtuins, and increases in N...

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Vydáno v:Aging Cell
Hlavní autoři: Moroz, Natalie, Carmona, Juan J, Anderson, Edward, Hart, Anne C, Sinclair, David A, Blackwell, T Keith
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2014
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4244309/
https://ncbi.nlm.nih.gov/pubmed/25257342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12273
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