Growth hormone signaling is necessary for lifespan extension by dietary methionine

Growth hormone significantly impacts lifespan in mammals. Mouse longevity is extended when growth hormone (GH) signaling is interrupted but markedly shortened with high-plasma hormone levels. Methionine metabolism is enhanced in growth hormone deficiency, for example, in the Ames dwarf, but suppress...

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Publicado en:Aging Cell
Main Authors: Brown-Borg, Holly M, Rakoczy, Sharlene G, Wonderlich, Joseph A, Rojanathammanee, Lalida, Kopchick, John J, Armstrong, Vanessa, Raasakka, Debbie
Formato: Artigo
Idioma:Inglês
Publicado: BlackWell Publishing Ltd 2014
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4244257/
https://ncbi.nlm.nih.gov/pubmed/25234161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12269
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