A maximum entropy approach to the study of residue-specific backbone angle distributions in α-synuclein, an intrinsically disordered protein

α-Synuclein is an intrinsically disordered protein of 140 residues that switches to an α-helical conformation upon binding phospholipid membranes. We characterize its residue-specific backbone structure in free solution with a novel maximum entropy procedure that integrates an extensive set of NMR d...

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Bibliographic Details
Published in:Protein Sci
Main Authors: Mantsyzov, Alexey B, Maltsev, Alexander S, Ying, Jinfa, Shen, Yang, Hummer, Gerhard, Bax, Ad
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243998/
https://ncbi.nlm.nih.gov/pubmed/24976112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2511
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