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The membrane protein Pannexin1 forms two open channel conformations depending on the mode of activation

Pannexin1 (Panx1) participates in several signaling events that involve ATP release, including the innate immune response, ciliary beat in airway epithelia and oxygen supply in the vasculature. The view that Panx1 forms a large ATP-release channel has been challenged by the association of a low cond...

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Publicat a:Sci Signal
Autors principals: Wang, Junjie, Ambrosi, Cinzia, Qiu, Feng, Jackson, David G., Sosinsky, Gina, Dahl, Gerhard
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243966/
https://ncbi.nlm.nih.gov/pubmed/25056878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005431
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