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Retrospective evaluation of methotrexate elimination when co-administered with proton pump inhibitors

AIMS: The aim was to assess potential interaction between methotrexate (MTX) and proton pump inhibitors (PPIs) in patients receiving high-dose MTX. METHODS: Records of 56 adults receiving 201 cycles of MTX were reviewed to determine effects of PPI administration on MTX elimination. Repeated-measures...

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Pubblicato in:Br J Clin Pharmacol
Autori principali: Reeves, David J, Moore, Elizabeth S, Bascom, Devon, Rensing, Brandon
Natura: Artigo
Lingua:Inglês
Pubblicazione: BlackWell Publishing Ltd 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243907/
https://ncbi.nlm.nih.gov/pubmed/24646036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12384
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