Effects of HM30181, a P-glycoprotein inhibitor, on the pharmacokinetics and pharmacodynamics of loperamide in healthy volunteers

AIMS: HM30181 is a third generation P-glycoprotein (P-gp) inhibitor currently under development. The objectives of this study were to evaluate the effects of a single dose of HM30181 on the pharmacodynamics and pharmacokinetics of loperamide, a P-gp substrate, and to compare them with those of quini...

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Publicado en:Br J Clin Pharmacol
Autores principales: Kim, Tae-Eun, Lee, Howard, Lim, Kyoung Soo, Lee, SeungHwan, Yoon, Seo-Hyun, Park, Kyung-Mi, Han, Hyesun, Shin, Sang-Goo, Jang, In-Jin, Yu, Kyung-Sang, Cho, Joo-Youn
Formato: Artigo
Lenguaje:Inglês
Publicado: BlackWell Publishing Ltd 2014
Materias:
Drug Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243906/
https://ncbi.nlm.nih.gov/pubmed/24602137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12368
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