Tolerability, pharmacokinetics and pharmacodynamics of TA-8995, a selective cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects

AIMS: Two double-blind, randomized studies were conducted to assess the tolerability, pharmacokinetics and pharmacodynamics of oral TA-8995, a new cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects. METHODS: Study 1: Subjects received single doses of TA-8995 or placebo (fasted)...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Ford, John, Lawson, Matt, Fowler, David, Maruyama, Nobuko, Mito, Seiji, Tomiyasu, Koichi, Kinoshita, Shuji, Suzuki, Chisa, Kawaguchi, Atsuhiro, Round, Patrick, Boyce, Malcolm, Warrington, Steve, Weber, Werner, van Deventer, Sander, Kastelein, John J P
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Pharmacodynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243901/
https://ncbi.nlm.nih.gov/pubmed/24628035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12380
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