Rosiglitazone Causes Cardiotoxicity via Peroxisome Proliferator-Activated Receptor γ-Independent Mitochondrial Oxidative Stress in Mouse Hearts

This study aims to test the hypothesis that thiazolidinedione rosiglitazone (RSG), a selective peroxisome proliferator-activated receptor γ (PPARγ) agonist, causes cardiotoxicity independently of PPARγ. Energy metabolism and mitochondrial function were measured in perfused hearts isolated from C57BL...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: He, Huamei, Tao, Hai, Xiong, Hui, Duan, Sheng Zhong, McGowan, Francis X., Mortensen, Richard M., Balschi, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Nanotoxicology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243497/
https://ncbi.nlm.nih.gov/pubmed/24449420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu015
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