Modulation of erythrocyte membrane mechanical stability by 2,3-diphosphoglycerate in the neonatal poikilocytosis/elliptocytosis syndrome.

To explain the transient anemia and poikilocytosis seen during infancy in hereditary elliptocytosis (HE), we resealed erythrocyte (RBC) ghosts from affected children or their elliptocytic parents with 2,3-diphosphoglycerate (DPG) (0-8 mM), a compound that dissociates membrane skeletons, then measure...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Main Authors: Mentzer, W C, Iarocci, T A, Mohandas, N, Lane, P A, Smith, B, Lazerson, J, Hays, T
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 1987
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC424243/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3818955/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112905
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