sn-1,2-Diacylglycerols and phorbol diesters stimulate thromboxane synthesis by de novo synthesis of prostaglandin H synthase in human promyelocytic leukemia cells.

We studied the regulation of thromboxane (TX) synthesis in promyelocytic leukemia cells during macrophage differentiation. Cells treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) showed rates of TXB2 synthesis from exogenous arachidonic acid that exceeded that of control cells by a factor of u...

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Publicat a:J Clin Invest
Autors principals: Goerig, M, Habenicht, A J, Heitz, R, Zeh, W, Katus, H, Kommerell, B, Ziegler, R, Glomset, J A
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 1987
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC424233/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3102559/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112900
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