Whole-Genome Scans Provide Evidence of Adaptive Evolution in Malawian Plasmodium falciparum Isolates

BACKGROUND: Selection by host immunity and antimalarial drugs has driven extensive adaptive evolution in Plasmodium falciparum and continues to produce ever-changing landscapes of genetic variation. METHODS: We performed whole-genome sequencing of 69 P. falciparum isolates from Malawi and used popul...

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Publicado en:J Infect Dis
Autores principales: Ocholla, Harold, Preston, Mark D., Mipando, Mwapatsa, Jensen, Anja T. R., Campino, Susana, MacInnis, Bronwyn, Alcock, Daniel, Terlouw, Anja, Zongo, Issaka, Oudraogo, Jean-Bosco, Djimde, Abdoulaye A., Assefa, Samuel, Doumbo, Ogobara K., Borrmann, Steffen, Nzila, Alexis, Marsh, Kevin, Fairhurst, Rick M., Nosten, Francois, Anderson, Tim J. C., Kwiatkowski, Dominic P., Craig, Alister, Clark, Taane G., Montgomery, Jacqui
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2014
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Major Articles and Brief Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4241944/
https://ncbi.nlm.nih.gov/pubmed/24948693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiu349
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